منابع مشابه
The Success Story of LDL Cholesterol Lowering.
We can look back at >100 years of cholesterol research that has brought medicine to a stage where people at risk of severe or fatal coronary heart disease have a much better prognosis than before. This progress has not come about without resistance. Perhaps one of the most debated topics in medicine, the cholesterol controversy, could only be brought to rest through the development of new clini...
متن کاملEffects of lowering LDL cholesterol on progression of kidney disease.
Lowering LDL cholesterol reduces the risk of developing atherosclerotic events in CKD, but the effects of such treatment on progression of kidney disease remain uncertain. Here, 6245 participants with CKD (not on dialysis) were randomly assigned to simvastatin (20 mg) plus ezetimibe (10 mg) daily or matching placebo. The main prespecified renal outcome was ESRD (defined as the initiation of mai...
متن کاملApoA-IV phenotype affects diet-induced plasma LDL cholesterol lowering.
The National Cholesterol Education Program (NCEP) recommends that dietary total fat, saturated fat, and cholesterol intake be reduced to < or = 30% of calories, < 10% of calories, and < 300 mg/d, respectively (step 1 diet), in the general population to reduce plasma low-density lipoprotein cholesterol (LDL-C) levels and heart disease risk. We examined the LDL-C-lowering response to such a diet ...
متن کاملShort-term LDL cholesterol-lowering efficacy of plant stanol esters
BACKGROUND The short-term cholesterol-lowering efficacy of plant stanol esters has been open to debate, and the data from different clinical studies with hypercholesterolemic subjects are variable, partly due to lack of systematic studies. Therefore, we investigated the time in days needed to obtain the full cholesterol-lowering effect of stanol esters in hypercholesterolemic subjects. METHOD...
متن کاملLowering LDL cholesterol is good, but how and in whom?
Genetic findings reported approximately 9 years ago in the Journal indicated that rare sequence variants in the gene encoding proprotein convertase subtilisin–kexin type 9 serine protease (PCSK9) were associated with significantly lower long-term plasma levels of low-density lipoprotein (LDL) cholesterol.1 The observed reduction in LDL cholesterol levels was similar to that attained with modera...
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ژورنال
عنوان ژورنال: Circulation
سال: 1999
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.99.8.e1